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Standardized Visual Data. Objective Performance Outcomes.

CaptureProof enables pharmaceutical sponsors, CROs, and clinical investigators to collect, manage, review, and analyze standardized medical photos and videos across clinical trials and observational studies. Computer vision transforms selected video assessments into quantitative measures of motor function and longitudinal change, supporting computational performance outcome measures (Computational PerfO) and digital biomarker research.

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CaptureProof offers:

Standardized Visual Data.

Objective Performance Outcomes.

Constant Up-to-Date Data Access

Quickly and securely access study results, updated in real time

Structured Research Data and Regulatory Review Support

Organize study media, reviewer access, and measurement outputs to support sponsor documentation and regulatory review.

Comparative organization

Automatic side-by-side of subject media

Computer Vision Measurements

Analyze standardized video assessments to quantify movement timing, gait, range of motion, symmetry, and longitudinal functional change.

Custom Protocols

Ensure accurate data and proper following of protocol

Structured Questions/Surveys

Get the answers you need from subjects or investigators

CaptureProof is a standardized visual data and computational measurement platform for clinical research.

Easily manage medical media & compare progress. Objectively document the impact an intervention is having on a patient. CaptureProof complements clinician assessments and patient-reported outcomes with quantitative measurements derived from standardized medical photos and videos. It also allows for a central reader.

HIPAA SECURE: PHOTOS | VIDEOS | CHAT | PDF | OUTCOMES

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Digital Check Up

Send a Personalized Pathway to Any Patient. Anytime.

Digital Check Up

Send a Personalized Pathway to Any Patient. Anytime.

Effectiveness Proven by Studies

Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study

European Journal of Neurology JANUARY 2021

RESULTS:

Forty‐four patients (31 women, age 45.1 years [r = 20–82]) were included and 530 SVs were viewed by a mean of seven experts and six residents; one video per patient was reviewed for a mean of 133.8 s (r = 9–543).
In all, 30 patients had PNEAs, 11 had ESs, and three had PhysNEEs.
Quality was suitable in 70.8% of SVs (375/530 total views), with 36/44 (81.8%) patient SVs rated as adequate by the majority of reviewers.
Accuracy improved with the presence of convulsive features from 72.4% to 98.2% in ESs and from 71.1% to 95.7% in PNEAs.
An accurate diagnosis was given by all reviewers (100%) in 11/44 SVs (all PNEAs).
Audio was rated as good by 86.2% of reviewers for these SVs compared with 75.4% for the remaining SVs (p = 0.01).
Lighting was better in SVs associated with high accuracy (p = 0.06), but clarity was not (p = 0.59).
Poor video quality yielded unknown diagnoses in 24.2% of the SVs reviewed.
Features hindering diagnosis were limited interactivity, restricted field of view and short video duration.

William O. Tatum, Lawrence J. Hirsch, Michael A. Gelfand, Emily K. Acton, W. Curt LaFrance, Robert B. Duckrow, David Chen, Andrew S. Blum, John Hixson, Joe Drazkowski, Selim Benbadis, Gregory D. Cascino, The OSmartViE Collaborators

ASSESSMENT OF THE PREDICTIVE VALUE OF OUTPATIENT SMARTPHONE VIDEOS FOR DIAGNOSIS OF EPILEPTIC SEIZURES

JAMA NEUROLOGY JANUARY 2020

RESULTS:

The odds of receiving a correct diagnosis were 5.45 times greater using smartphone video alongside patient history and physical examination results than with history and physical examination alone (95% CI, 1.01-54.3; P = .02)
One-fourth of the smartphone videos were correctly diagnosed by 100% of the reviewing physicians, composed solely of psychogenic attacks.
When histories and physical examination results were combined with smartphone videos, correct diagnoses rose from 78.6% to 95.2%.

William O. Tatum, DO¹; Lawrence J. Hirsch, MD²; Michael A. Gelfand, MD³; Emily K. Acton, BS³; W. Curt LaFrance Jr, MD, MPH⁴; Robert B. Duckrow, MD²; David K. Chen, MD⁵; Andrew S. Blum, MD⁴; John D. Hixson, MD⁶; Joe F. Drazkowski, MD⁷; Selim R. Benbadis, MD⁸; Gregory D. Cascino, MD⁹; for the OSmartViE Investigators

¹Department of Neurology, Mayo Clinic, Jacksonville, Florida
²Department of Neurology, Yale University, New Haven, Connecticut
³Department of Neurology, University of Pennsylvania, Philadelphia
⁴Department of Neurology, Brown University, Providence, Rhode Island
⁵Department of Neurology, Baylor College of Medicine, Houston, Texas
⁶University of California, San Francisco, San Francisco
⁷Department of Neurology, Mayo Clinic, Phoenix, Arizona
⁸Department of Neurology, University of South Florida, Tampa
⁹Department of Neurology, Mayo Clinic, Rochester, Minnesota

Noninvasive assessment of liver steatosis in deceased donors: A pilot study

JOURNAL OF LIVER TRANSPLANTATION DECEMBER 2017

CONCLUSION: Study proves for the first time, the feasibility of analysis of smartphone image parameters as technique for steatosis assessment in liver graft

Manuela Cesaretti, Nicolas Poté, Francois Cauchy, Federica Dondero, Safi Dokmak, Ailton Sepulveda, Anne Sophie Schneck, Claire Francoz, Francois Durand, Valerie Paradis and Olivier Soubrane PARIS, FRANCE

Outpatient Smartphone Videos for Classifying Epileptic and Nonepileptic Seizures

PRESENTED AT AMERICAN EPILEPSY SOCIETY MEETING 2017

CONCLUSION: Secure uploading, exchange, and analysis of SV data in patients with paroxysmal neurological events is feasible. Most SVs were non-convulsive though those with the highest concordance among raters were PNES almost exclusively differing from H & P. The median duration of SV was 1min 28sec vs 60 mins with routine H & P and 2.54 days with VEM (p= < 0.0001).

William O. Tatum DO¹, Larry Hirsch MD², Robert Duckrow MD², David Chen MD³, Michael Gelfand MD PhD⁴, Curt LaFrance MD⁵, Andrew Blum MD⁵, John Hixson MD⁶, Joe Drazkowski MD¹, Selim Benbadis MD⁷, Diego Carvalho MD¹, Alfonso Lopez MD¹, Erin Okazaki MD¹, Iris Marin Collazo MD¹, Ashish Ranpura MD², Scott Yuan MD², Jon Kleen MD⁶, Erin Coonan⁸, Gregory Cascino MD¹
Departments of Neurology: ¹Mayo Clinic, ²Yale University, ³Baylor University, ⁴University of Pennsylvania, ⁵Brown University, ⁶University of California San Francisco, ⁷University of South Florida, ⁸Boston College

Outpatient Smartphone Videos in Epilepsy (OSmartViE): Initial Results of Video Quality

POSTER PRESENTED AT AMERICAN EPILEPSY SOCIETY MEETING DEC 2017

CONCLUSION: Smartphone Video (SV) are highly specific for ES diagnosis and highly sensitive to PNEA diagnosis. Most SV were adequate in clarity, audio and light according to physician review. SV were mostly limited by limited bystander interaction, lack of whole body view and ictal period recorded.

Erin E. Coonan¹, Lawrence J. Hirsch MD², Robert B. Duckrow MD², David Chen MD³, Michael Gelfand MD PhD⁴, Andrew Blum MD⁵, John Hixson MD⁶, William LaFrance MD⁵, Joseph Drazkowski MD¹, Selim Benbadis MD⁷, Gregory Cascino MD¹, William O. Tatum DO¹
Departments of Neurology: ¹Mayo Clinic, ²Yale University, ³Baylor University, ⁴University of Pennsylvania, ⁵Brown University, ⁶University of California San Francisco, ⁷University of South Florida

Noninvasive assessment of liver steatosis in deceased donors: a pilot study

POSTER PRESENTED AT 13éme Congrès Francophone de Chirurgie Digestive et Hépato-Bilio-Pancréatique 13th Congress of Digestive Surgery and Hepato Pancreatic Bilio

CONCLUSION: Study proves for the first time, the feasibility of analysis of smartphone image parameters as technique for steatosis assessment in liver graft.

Manuela Cesaretti¹ ², Nicolas Poté³, Francois Cauchy¹, Federica Dondero¹, Safi Dokmak¹, Ailton Sepulveda¹, Anne Sophie Schneck¹, Claire Francoz⁴, Francois Durand⁴, Valerie Paradis³, Olivier Soubrane¹
¹Beaujon Hospital, Department: HPB Surgery and Liver Transplantation; ²Istituto Italiano di Tecnologia; ³Hôpital Beaujon, Department: Pathology; ⁴Beaujon Hospital, Hepatology and Liver Intensive Care.

Outpatient Smartphone Videos in Epilepsy (OSmartViE): Initial Results

POSTER PRESENTED AT AMERICAN EPILEPSY SOCIETY DEC 2016

CONCLUSION: Secure exchange of Smartphone Video (SV) information is feasible. Most SV had convulsive episodes but 70% were not ES. SV diagnosis had a level of confidence similar to History & Physical. Epileptologists (71.4% accurate sv diagnostic rate) were better in identifying ES than trainees and more confident in non-epilepsy despite similar accuracy.

William O. Tatum DO¹, Larry Hirsch MD², Robert Duckrow MD², David Chen MD³, Michael Gelfand MD PhD⁴, Curt LaFrance MD⁵, Andrew Blum MD⁵, John Hixson MD⁶, Joe Drazkowski MD¹, Selim Benbadis MD⁷, Diego Carvalho MD¹, Alfonso Lopez MD¹, Erin Okazaki MD¹, Iris Marin Collazo MD¹, Ashish Ranpura MD², Scott Yuan MD², Jon Kleen MD⁶, Erin Coonan⁸, Gregory Cascino MD¹ Departments of Neurology: ¹Mayo Clinic, ²Yale University, ³Baylor University, ⁴University of Pennsylvania, ⁵Brown University, ⁶University of California San Francisco, ⁷University of South Florida, ⁸Boston University

TESTING feasibility and utility of remote data capture technology to assess parkinson’s disease

POSTER PRESENTED AT INTERNATIONAL PARKINSON AND MOVEMENT DISORDER SOCIETY BERLIN, GERMANY JUNE 2016

CONCLUSION:

High quality of home video recordings for asynchronous video-recordings are feasible in early to mid-stage PD using a HIPAA-compliant app and cloud-based platform
Ratings from the modified “svUPDRS” are in good agreement with scores on equivalent items from the in- person UPDRS
Two independent raters did not differ significantly in ratings on the video-based visits
1 hour in-office training is adequate for most patients
Asynchronous virtual visits are a novel tool for creating an archive of rich patient data beyond the scope & scale of what can be captured in a clinical setting

CLAIRE HENCHCLIFFE, MD DPhil, cornell medical center, new york, ny

REMOTE ASYNCHRONOUS TELEREHABILITATION FOLLOWING TOTAL KNEE ARTHROPLASTY

JOURNAL OF TELEMEDICINE TELECARE MARCH 2016

CONCLUSION: Overall utilization of hospital-based resources was 60% less than for the traditional group. We report that clinical outcomes following asynchronous telerehabilitation administered over the web and through a hand-held device were not inferior to those achieved with traditional care. Outpatient resource utilization was lower. Patient satisfaction was high for both groups. The results suggest that asynchronous telerehabilitation may be a more practical alternative to real-time video visits and are clinically equivalent to the in-person care model.

STEFANO BINI, MD, KAISER PERMANENTE, OAKLAND, CA

Use of Smartphone Application for Management of Postoperative Wound Complications

AUGUST 2013

CONCLUSION: Smartphone applications can serve as a useful tool in postoperative management of patients undergoing orthopaedic surgery.

Krzysztof B. Siemionow, MD, UNIVERSITY ILLINOIS CHICAGO, CHICAGO, IL

BENEFITS OF MEDICAL MEDIA IN PEDIATRIC NEUROLOGY

AWARDED “ORAL PRESENTATION” AT AAN POSTER SESSION APRIL 2013

CONCLUSION: CaptureProof EASY-TO-USE, NON-INVASIVE, SECURE SYSTEM FOR REAL-LIFE PATIENT MONITORING AT A FRACTION OF THE COST OF CURRENT STANDARDS WILL BENEFIT PATIENTS FROM THE VERY FIRST EVENT THROUGH DIAGNOSIS AND TREATMENT. THE STUDY DEMONSTRATED THE USEFULNESS OF MEDIA IN PEDIATRIC NEUROLOGY PRACTICES PROVING THAT IT: A) ALLOWS FOR FASTER AND MORE ACCURATE DIAGNOSIS, B) REDUCES THE NEED FOR COSTLY TESTS, ER/OFFICE VISISTS, AND LENGTHY HOSPITAL STAYS, C) OPTIMIZES TREATMENT MODALITIES AND D) RESULTS IN BETTER CARE AT A FRACTION OF THE COST OF THE CURRENT STANDARD OF CARE FOR PATIENTS.

FARHARD SAHEBKAR-MOGHADDAM, MD, SUTTER MEDICAL CENTER, SAN FRANCISCO, CA